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Clinical trials database - open trials

Open clinical trials in the NAPWA database are listed below – the most recently-added entries are shown at the top of the list.

(‘Open’ clinical trials are those listed as enrolling now or not yet started.)

QUAD

Clinical trial • Not yet started • 21 May 2010

A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Elvitegravir/Emtricitabine/Tenofovir Disoproxil Fumarate/GS-9350 Versus Ritonavir-Boosted Atazanavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults

TROP - low bone mineral density

Clinical trial • Enrolling • 22 January 2010

Switch From Tenofovir to Raltegravir for Low Bone Mineral Density
Tags: bone disorders, integrase inhibitor, raltegravir

UK-453, 061

Clinical trial • Enrolling • 24 March 2009

A Study Of Different Doses Of UK-453, 061 Plus Truvada Compared To Efavirenz Plus Truvada In Patients Who Have Not Been Previously Treated For HIV-1
Tags: drug resistance, NNRTI

Second line

Clinical trial • Enrolling • 26 June 2008

A Randomised Open-label Study Comparing the Safety and Efficacy of Ritonavir Boosted Lopinavir and 2-3N(t)RTI Backbone Versus Ritonavir Boosted Lopinavir and Raltegravir in Participants Virologically Failing First-line NNRTI/2N(t)RTI Therapy
Tags: first-line therapy, salvage therapy

ENCORE-1

Clinical trial • Not yet started • 27 June 2008

A Randomised, Double-blind, Placebo-controlled, Clinical Trial to Compare the Safety and Efficacy of Reduced Dose Efavirenz (EFV) With Standard Dose EFV Plus Two Nucleotide Reverse Transcriptase Inhibitors (N(t)RTI) in Antiretroviral-naïve HIV-infected Individuals Over 96 Weeks
Tags: clinical trials

START (Strategic Timing of AntiRetroviral Treatment)

Clinical trial • Enrolling • 9 April 2009

Strategic Timing of AntiRetroviral Treatment (START)
Tags: starting treatments

CMV and interferon

Clinical trial • Unknown • 17 February 2010

Evaluation of Interferon-Gamma Responses to HCMV Infection in HIV Positive Individuals
Tags: CMV, symptoms, illnesses and opportunistic infections

Treating influenza

Clinical trial • Enrolling • 19 February 2010

A Randomized Open Label Study Comparing the Efficacy, Safety, and Tolerability of Oral Administration of Amantadine and Ribavirin With Oseltamivir Versus Oseltamivir to Influenza A Virus Infected Immunocompromised Subjects
Tags: symptoms, illnesses and opportunistic infections

Pharmacist prescribing study

Clinical trial • Enrolling • 19 February 2010

The Evaluation of the Impacts of a Doctor – Pharmacist Collaborative Prescribing Model on the Management of Human Immunodeficiency Virus (HIV) Infected Patients
Tags: Accessing HIV care and treatment

PHIIDO - disease progression

Clinical trial • Enrolling • 19 February 2010

A prospective cohort study of individuals with primary Human Immunodefiency Virus (HIV) infection to determine immunological and virological factors related to disease progression.
Tags: pathogenesis

Immune responses to hepatitis B

Clinical trial • Unknown • 19 February 2010

Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
Tags: hepatitis B

'Naive T-cell' study

Clinical trial • Unknown • 17 February 2010

Role of Naive T-Cells in the Pathogenesis of T-Cell Decline and Long Term Persistence of HIV
Tags: newly diagnosed, pathogenesis, primary HIV infection

Impact of HIV and Its Treatment on Reverse Cholesterol Transport

Clinical trial • Enrolling • 22 October 2008

Impact of HIV Infection and Treatment With Highly Active Antiretroviral Therapy on Reverse Cholesterol Transport
Tags: heart disease

The Structured Treatment Interruption (STI) Study

Clinical trial • Not yet started • 22 October 2008

A Randomized, Multicenter Trial to Determine Whether Induction Therapy Followed by Treatment Interruption is Superior to Induction Therapy Alone in the Treatment of Primary HIV Infection (PHI): The Structured Treatment Interruption (STI) Study

Predictors of drug hypersensitivity

Clinical trial • Enrolling • 11 May 2007

Predictors of Drug Hypersensitivity in HIV-infected subjects
Tags: hypersensitivity reactions

HIV/HBV coinfection and liver disease

Clinical trial • Enrolling • 11 May 2007

Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) co-Infection and Liver Disease
Tags: hepatitis B, liver disorders

HIV/HBV coinfection and tenofovir resistance

Clinical trial • Enrolling • 28 March 2008

A surveillance program for the detection of hepatitis B virus (HBV) resistance to tenofovir (TDF) in HIV-HBV co-infected patients
Tags: hepatitis B

HIV/HBV or HIV/HCV coinfection

Clinical trial • Enrolling • 23 April 2008

A Study of Innate Immunity in HIV Positive Patients co-Infected With Hepatitis C or Hepatitis B
Tags: hepatitis B, hepatitis C, innate immunity