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Clinical trials database - closed trials

Closed clinical trials in the NAPWHA database are listed below – the most recently-added entries are shown at the top of the list.

(‘Closed’ clinical trials include those listed as fully enrolled, concluded, or cancelled.)

SAILING

Clinical trial • No longer enrolling • 3 November 2010

A Randomized, Double-blind Study of the Safety and Efficacy of GSK1349572 50 mg Once Daily Versus Raltegravir 400 mg Twice Daily, Both Administered With an Investigator-selected Background Regimen Over 48 Weeks in HIV-1 Infected, Integrase Inhibitor-Naïve, Antiretroviral-Experienced Adults

SPRING 2

Clinical trial • No longer enrolling • 3 November 2010

This is a Randomized, Double Blind Study to look at the Safety and Efficacy of a novel Integrase Inhibitor (II) Dolutegravir at a dosage of 50mg taken once a day compared with Raltegravir 400mg taken twice a day. Both 'arms' are Administered With Fixed-dose Dual Nucleoside Reverse Transcriptase Inhibitor (NRTI) Therapy Over 96 Weeks among people with HIV who have not previously taken Antiretroviral Therapy.

MODERN (Maraviroc versus Truvada)

Clinical trial • No longer enrolling • 19 January 2012

A Multicenter, Randomized, Double Blind, Comparative Trial Of Maraviroc + Darunavir/Ritonavir Versus Emtricitabine/Tenofovir +Darunavir/Ritonavir For The Treatment Of Antiretroviral-Naïve HIV Infected Patients With Ccr5 Tropic HIV 1
Tags: maraviroc

Famciclovir for genital herpes

Clinical trial • Concluded • 7 February 2012

A Single Center, Open Label, Longitudinal Single Arm Study to Compare the Efficacy and Safety of Prophylactic Famciclovir 500 mg b.d. in HIV Positive Adults With Recurrent Genital Herpes.
Tags: genital herpes

RETRIeVE

Clinical trial • Concluded • 24 January 2012

Non-nucleoside Reverse Transcriptase Inhibitor Failure in a High HIV Caseload Australian Primary Care Practice

Cobicistat and renal function

Clinical trial • Fully enrolled • 16 January 2012

A Phase 3 Open-label Safety Study of Cobicistat-containing Highly Active Antiretroviral Regimens in HIV-1 Infected Patients With Mild to Moderate Renal Impairment

CNS HAND

Clinical trial • Fully enrolled • 23 November 2011

The CNS HAND Study: The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort

Lersivirine long term safety study

Clinical trial • Cancelled • 25 March 2011

A Long Term Open-Label Extension Study of Lersivirine For The Treatment Of HIV-1 Infection

SPARTA

Clinical trial • Reported • 21 August 2009

A Randomised, Open-Label, Cross-Over Study to Examine the Pharmacokinetics and Short-Term Safety and Efficacy of Two Dosing Strategies of Raltegravir Plus Atazanavir in HIV-Infected Patients
Tags: atazanavir, first-line therapy, raltegravir

Gardasil for young men

Clinical trial • Reported • 16 January 2012

An Investigational Vaccine in Reducing the Incidence of Anogenital Warts in Young Men
Tags: anal cancer, HPV

ENCORE-1

Clinical trial • Fully enrolled • 27 June 2008

A Randomised, Double-blind, Placebo-controlled, Clinical Trial to Compare the Safety and Efficacy of Reduced Dose Efavirenz (EFV) With Standard Dose EFV Plus Two Nucleotide Reverse Transcriptase Inhibitors (N(t)RTI) in Antiretroviral-naïve HIV-infected Individuals Over 96 Weeks
Tags: clinical trials

ATRAS

Clinical trial • Fully enrolled • 19 October 2011

AHOD Temporary Residents Access Study

Second line

Clinical trial • Fully enrolled • 26 June 2008

A Randomised Open-label Study Comparing the Safety and Efficacy of Ritonavir Boosted Lopinavir and 2-3N(t)RTI Backbone Versus Ritonavir Boosted Lopinavir and Raltegravir in Participants Virologically Failing First-line NNRTI/2N(t)RTI Therapy
Tags: first-line therapy, salvage therapy

VERxVE (fast and slow release nevirapine)

Clinical trial • Reported • 28 March 2008

A Randomised, Double Blind, Double Dummy, Parallel Group, Active Controlled Trial to Evaluate the Antiviral Efficacy of 400 mg QD Nevirapine Extended Release Formulation in Comparison to 200 mg BID Nevirapine Immediate Release in Combination With Truvada? in Antiretroviral Therapy Naive HIV-1 Infect
Tags: liver disorders, optimised background regimens, treatment side effects

Treating influenza

Clinical trial • Cancelled • 19 February 2010

A Randomized Open Label Study Comparing the Efficacy, Safety, and Tolerability of Oral Administration of Amantadine and Ribavirin With Oseltamivir Versus Oseltamivir to Influenza A Virus Infected Immunocompromised Subjects
Tags: symptoms, illnesses and opportunistic infections

'Booster' study

Clinical trial • No longer enrolling • 3 August 2010

Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of GS-9350-boosted Atazanavir Versus Ritonavir-boosted Atazanavir Each Administered With Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults

Single

Clinical trial • No longer enrolling • 14 March 2011

A Randomized, Double-Blind Study of the Safety and Efficacy of GSK1349572 Plus Abacavir/Lamivudine Fixed-Dose Combination Therapy Administered Once Daily Compared to Atripla Over 96 Weeks in HIV-1 Infected Antiretroviral Therapy Naive Adult Subjects

UK-453, 061

Clinical trial • Concluded • 24 March 2009

A Study Of Different Doses Of UK-453, 061 Plus Truvada Compared To Efavirenz Plus Truvada In Patients Who Have Not Been Previously Treated For HIV-1
Tags: drug resistance, NNRTI

ALTAIR (Truvada for treatment-naive)

Clinical trial • Reported • 11 May 2007

A Randomised Open-Label Study Comparing the Safety and Efficacy of Three Different Combination Antiretroviral Regimens as Initial Therapy for HIV Infection
Tags: first-line therapy, starting treatments

CMV and interferon

Clinical trial • Concluded • 17 February 2010

Evaluation of Interferon-Gamma Responses to HCMV Infection in HIV Positive Individuals
Tags: CMV, symptoms, illnesses and opportunistic infections

TMC125 (etravirine) for people who failed on the DUET studies

Clinical trial • Reported • 10 May 2007

An Open-Label Trial with TMC125 in Patients Who Have Virologically Failed in a DUET Trial (TMC125-C206 or TMC125-C216)

Impact of HIV and Its Treatment on Reverse Cholesterol Transport

Clinical trial • No longer enrolling • 22 October 2008

Impact of HIV Infection and Treatment With Highly Active Antiretroviral Therapy on Reverse Cholesterol Transport
Tags: heart disease

PINT (including raltegravir)

Clinical trial • Fully enrolled • 11 April 2008

The Effect of Raltegravir on HIV Decay During Primary and Chronic Infection (PINT)

Rapid Testing

Clinical trial • Fully enrolled • 24 March 2011

Do homosexual men test more frequently for human immunodeficiency virus (HIV) with rapid tests? A randomised controlled trial.

QUAD

Clinical trial • No longer enrolling • 21 May 2010

A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Elvitegravir/Emtricitabine/Tenofovir Disoproxil Fumarate/GS-9350 Versus Ritonavir-Boosted Atazanavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults