Recently diagnosed with HIV? Click here

Lower dosing trial funded

Positive Living article • Adrian Ogier • 5 June 2009
iStockPhoto/DivaniR4A
iStockPhoto/DivaniR4A

The Bill and Melinda Gates Foundation has granted AUD $12.4 million to the University of NSW to study whether lower doses of some commonly used antiretroviral drugs are as effective as currently prescribed doses.

The trial will start by comparing the standard 600mg dose of efavirenz with a lower dose of 400mg once daily. As well, the study anticipates finding the optimum doses of other antiretroviralsA medication or other substance which is active against retroviruses such as HIV. including lamivudine, ritonavir-boosted lopinavir, ritonavir-boosted atazanavir, and zidovudine.

Participants from different parts of the world will be enrolledThe act of signing up participants into a study. Generally this process involves evaluating a participant with respect to the eligibility criteria of the study and going through the informed consent process. to compare the results of those on the current recommended doses with those on the new, lower doses.

Potentially, this study could lead to us using antiretrovirals more efficiently. By avoiding larger doses than necessary we can provide more affordable treatment options for large populations in resource limited settings.

  • Delicious
  • Digg
  • StumbleUpon
  • Reddit
  • Facebook
  • Google
  • Yahoo
  • Technorati
Text size: font smallerfont normalfont larger print-friendly version of this pagePDF version of this pageemail this page to a friend

From Positive Living

This article was first published in the June 2009 issue of Positive Living — more than three years ago.

While the content of this was checked for accuracy at the time of publication, NAPWHA recommends checking to determine whether the information is the most up-to-date available, especially when making decisions which may affect your health.

This article may contain medical information. NAPWHA makes every reasonable effort to ensure the information on this website is accurate, reliable and up-to-date, including obtaining technical reviews by medically-qualified reviewers, however the authors of information on this website are not qualified to give medical advice, except where explicitly stated.

The content of this website is intended to support, not replace, the relationship between people living with HIV/AIDS and their medical advisers, and is not intended as a substitute for medical advice.

HIV Clinical Trials update

Recently updated entries from the NAPWHA Clinical Trials database.

more